Deep Hydration 48 Hour Activation Serum

Deep Hydration 48 Hour Activation Serum


Skin type:  For dry or dehydrated, sensitive skin

This lightweight serum instantly absorbs by deeply replenishing skin's hydration for 48 hours and improving the overall quality of sensitive skin. Formulated with Hyaluronic Acid plus sunflower seed oil to immediately smooth the skin's texture and restores skin's radiant appearance.

  • Features our exclusive HydroSensitiv Complex™ with soothing blue daisy to deepen dynamic hydration and soothe skin to improve the quality of sensitive skin over time .
  • Layerable serum that instantly absorbs to improve the quality of sensitive skin over time .
  • Nourishes and replenishes skin's hydration for 48 hours .
  • Dermatologist tested and clinically proven to be gentle on sensitive skin.





This creamy serum instantly absorbs to deliver deep 48-hour hydration. Featuring our exclusive HydroSensitiv Complex™ with soothing blue daisy to deepen dynamic hydration and soothe skin and improve the quality of sensitive skin over time. Plus hyaluronic acid, sunflower seed oil, vitamin B5, and antioxidant-rich vitamin E to rehydrate and restore skin's appearance. This layerable serum Instantly absorbs and can be used alone or with Deep Hydration Healthy Glow Daily Cream for an extra boost to skin's hydration. Ideal for sensitive, dry or dehydrated skin. Defends against 5 signs of skin sensitivity including dryness, irritation, roughness, tightness, and a weakened skin barrier.





  • Fragrance_Free

    Fragrance free

  • Paraben_Oil_

    Paraben free

  • Hypoallergenic


  • Wont_Clog_Pores

    Won't Clog Pores

  • 5-signs

    Defends against 5 signs of skin sensitivity




Deep Hydration 48 Hour Activation Serum
Deep Hydration 48 Hour Activation Serum Ingredients



Water, Glycerin, Sorbitol, Coco-Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Helianthus Annuus (Sunflower) Seed Oil, Octyldodecanol, Hexyldecanol, Hexyldecyl Laurate, Distarch Phosphate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Butyrospermum Parkii(Shea)Oil, Citric Acid, Dicaprylyl Carbonate, Disodium Cocoyl Glutamate, Globulariaalypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Panthenol (Vitamin B5), Pantolactone, Phenoxyethanol, Propylene Glycol, Sodium Benzoate, Sodium Hydroxide, Sodium Polyacrylate, Tocopherol (Vitamin E), Tocopheryl Acetate (Vitamin E Acetate), Xylitol, Xylitylglucoside



Apply a serum to add a boost to your routine

After cleansing, apply a serum to target specific skin concerns. When looking for a boost of hydration, apply Deep Hydration 48 Hour Activation Serum all over face and neck.


Apply a moisturizer to help your skin rehydrate, renew and repair

Using a moisturizer after a serum, such as Deep Hydration Healthy Glow Daily Cream, helps to boost skin’s moisture and protect skin from dryness all day so that skin looks and feels refreshed.


Target under-eye area for a refreshed look

Finish your moisturizing routine with Deep Hydration Refreshing Eye Serum to target the delicate skin under your eyes. Apply a pearl-sized amount around the eye area morning and night and smooth until absorbed, leaving your skin brighter and nourished. This eye cream is clinically proven to be gentle on sensitive skin.


Rated 1 out of 5 by from NO. This BURNED my eyes. I have NEVER had to write a review like this, but I am sitting here in serious pain with this chemical burn on my eyes from this product. I have never had a reaction to any other product like I have with this one, and have enjoyed using other Cetaphil products. It feels as though someone rubbed sandpaper over my delicate skin, and has become so red, painful, dry, cracked and rough, after IMMEDIATE use. Again, I have never written reviews or any other problems with products.... so the fact that I am writing this, means it is BAD. I have to literally put ice packs on my eyes just to make them feel better, as now, I can’t even put any other product on this skin, since it’s so damaged, everything hurts. Only time will let this skin heal.
Date published: 2021-04-30
Rated 3 out of 5 by from Hydrating but... All skincare products take time before you start to notice any changes. With that being said, I have been using this product daily over the course of about 3 weeks. I tried using it in the morning however with the hyaluronic acid and moisturizing ingredients in this product, it left my eyes feeling and looking a bit glossy. I switched to using it in my nightly skincare routine and I do like it better that way. I feel it has helped a bit with the dryness but I am personally looking for something a bit more in depth for the developing fine lines that come with the aging process. It is also unscented, which is great for those with sensitivities.
Date published: 2020-11-03
Rated 5 out of 5 by from Amazing I've been using this eye cream for about a week and I'm super impressed. I have severe eczema on my face, especially my eyelids which leave me with extremely dry, puffy, flaking eyelids. At first this cream burned when I applied it, but it wasn't awful and didn't last long especially compared to other creams and even prescriptions I've tried. Now after a week, the skin around my eyes is smooth and feels like normal, hydrated skin again! This cream has been a life saver for me. Cetaphil makes the best products for people like me who have dry, sensitive, eczema prone skin! Highly recommend this eye serum to anyone suffering from dry, flaky eyelids.
Date published: 2021-05-04
Rated 5 out of 5 by from Old woman First time I bought the hydrating eye gel cream in target 6 months ago. I am 67 years old and this cream helps me a lot to hydrate and locks moisture under my eye area skin. I use this cream twice a day.
Date published: 2021-03-18
Rated 4 out of 5 by from Good but not great I was really excited to receive this in a VoxBox and test this eye serum out since I wasnt using one already. Ive been using this everyday for about 3 weeks now. I like the serum but didnt notice any dramatic improvement to my under eyes. I still had to use an eye cream to keep my under eyes hydrated. I like the packaging, its really easy to get the cap off and on. The price is good! The product itself is thin and sinks into the skin quickly by just tapping it in with your ring fingers. It works well with my eye creams and didnt ball up at all. Had no scent as far as I could tell. I just wish I had seen an improvement in my under eyes to make it worth adding in an extra step into my skincare routine.
Date published: 2020-10-24
Rated 1 out of 5 by from Had horrible allergic reaction As recommended by my dermatologist, I use Cetaphil lotion (both body lotion and facial) and it works great. Tried this eye serum and had a horrible reaction. My eyelids and along the sides of my nose/eyes and under my eyes all swelled up. I also had patchy rashes all around and terrible itching. It’s been three days since I tried it and my eyelids are still a mess and itchy.
Date published: 2022-01-21
Rated 1 out of 5 by from burning and red I purchased this to replace my normal hyaluronic acid serum, as it was cheaper and geared toward sensitive skin. However, I have used this twice now, and both times my skin became extremely red, with a burning sensation. I have washed my face and taken Benadryl to help... with no luck. If you truly have sensitive skin, I encourage you to keep a receipt and do a patch test.
Date published: 2022-04-08
Rated 1 out of 5 by from Burns my skin I bought this thinking that it would be a good product for the dry sensitive skin around my eyes. I was very wrong. It stings and burns when applied, and the stinging lasts for hours. After applying it just before bed, I woke up with flaky peeling skin all around my eyes. I assumed any product from Cetaphil would be gentle and effective but this is not the one.
Date published: 2021-07-12
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